Seminars
Wednesday 21st January 2009
Programme:
- 5-5.20pm: "An Introduction to Radiopharmaceutical Imaging Agents" By Prof Vaughan Griffiths
- 5.20-5.30pm: Discussion
- 5.30-5.50pm: Topic Tbc. By Prof. Martin Rothman
- 5.50-6pm: Discussion
- 6-7pm: Refreshments
Speakers:
Professor Vaughan GriffithsResearch Professor in Organic Chemistry Biological and Chemical Sciences
Our current research interests can be divided into two main areas.
1. The development of new radiopharmaceutical agents for imaging and therapy
We have been collaborating with GE Healthcare (formerly Amersham plc) for over 20 years on the development of a range of new radiopharmaceutical agents for imaging and therapy, particularly those based on the isotope Tc-99m, which are used for medical imaging. Our work involves the synthesis of novel functionalised polydentate ligands containing a combination of phosphorus, nitrogen, sulphur and oxygen donor atoms, which can be linked to biological targeting units.
2. Mechanistic and synthetic studies in organophosphorus chemistry.
We have been interested for some time in the way in which trivalent phosphorus compounds react with electrophilic organic compounds and the nature of the intermediates involved. NMR spectroscopy is particularly well suited for this type of work and it is often possible to identify the reaction pathways followed and the types of reactive intermediate involved by monitoring the reactions of the phosphorus compound with the organic molecules over a range of conditions. We have then been able to exploit this information to develop novel synthetic routes to some interesting new products. Current work involves studies on heteroaromatic aroylphosphonates and a range of other carbonyl-containing systems.
Email: d.v.griffiths@qmul.ac.uk
Prof. Martin Rothman, Professor of Interventional Cardiology, Director of Cardiac R&D
William Harvey Research Institute
The Cardiac and Cardiology Department is a fully integrated and internationally recognised research unit, dedicated to comprehensive research into clinical electrophysiology and interventional cardiology. Our strategy is built on a foundation to provide world class patient care by uncovering and establishing unique opportunities for treatment through the investigation and cure of abnormal heart rhythms.
